Pathguide: the pathway resource list
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Full Record: Negatome  
Short NameNegatome
Full NameThe Negatome Database
Last ObservedMarch 13th, 2017
DescriptionThe Negatome database is a collection of protein and domain pairs which are unlikely engaged in direct physical interactions. The database currently contains experimentally supported non-interacting protein pairs derived from two distinct sources: by manual curation of literature and by analyzing protein complexes from the PDB. More stringent lists of non-interacting pairs were derived from these two datasets by excluding interactions from IntAct.
Sample Data URL 
Data SourceSecondary
AvailabilityFree to all users
PubMed ArticlesThe Negatome database: a reference set of non-interacting protein pairs.
Smialowski P, Pagel P, Wong P, Brauner B, Dunger I, Fobo G, Frishman G, Montrone C, Rattei T, Frishman D, Ruepp A.
Nucleic Acids Res. 2010 Jan;38(Database issue):D540-4.

Negatome 2.0: a database of non-interacting proteins derived by literature mining, manual annotation and protein structure analysis.
Blohm P, Frishman G, Smialowski P, Goebels F, Wachinger B, Ruepp A, Frishman D.
Nucleic Acids Res. 2014 Jan;42(Database issue):D396-400.

Types of DataProtein-Protein Interactions
Types of ToolsText mining, Interaction or functional association prediction
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Last Content Update: October 4th, 2013
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Relative Popularity5
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"Pathguide: the pathway resource list" is maintained by Gary Bader1.
The website was originally created by Michael Cary 2 and was significantly updated and redesigned by Vuk Pavlovic1.
Thanks to Emek Demir for the Pathguide name.

1. Bader Lab
2. Sander Group

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