Pathguide: the pathway resource list
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Full Record: SPIKE  
Short NameSPIKE
Full NameSignaling Pathway Integrated Knowledge Engine
Last ObservedMarch 2nd, 2017
DescriptionSPIKE (Signaling Pathway Integrated Knowledge Engine) is an interactive software environment that graphically displays biological signaling networks, allows dynamic layout and navigation through these networks, and enables the superposition of DNA microarray and other functional genomics data on interaction maps.

Users can download the database for use as a lab or as a single user.

The current curators of Spike are three PhDs and one PhD student. These researchers are specialists on the subjects of DNA damage response, Apoptosis, and Ear-related developmental processes. SPIKE data is human-oriented, but in a few cases where the data on specific regulation in humans is not available, we use also data from mice. During the process of curation, published data from the curator’s laboratories and data from resources that are open for the public are evaluated and a decision is made about the integrity of the data. Spike site has tripled since the 2008 publication cited regarding the regulation with high integrity and the number of pathway maps. 80% of the maps were updated during 2009, and half of the maps were updated during the last quarter of 2009.

Sample Data URL 
Data SourcePrimary
AvailabilityFree to academic users
PubMed ArticlesSPIKE--a database, visualization and analysis tool of cellular signaling pathways.
Elkon R, Vesterman R, Amit N, Ulitsky I, Zohar I, Weisz M, Mass G, Orlev N, Sternberg G, Blekhman R, Assa J, Shiloh Y, Shamir R.
BMC Bioinformatics. 2008 Feb 20;9:110

SPIKE: a database of highly curated human signaling pathways.
Paz A, Brownstein Z, Ber Y, Bialik S, David E, Sagir D, Ulitsky I, Elkon R, Kimchi A, Avraham KB, Shiloh Y, Shamir R
Nucleic Acids Res. 2011 Jan;39(Database issue):D793-9.

Types of DataSignaling Pathways, Pathway Diagrams
Types of ToolsPathway diagram tools
Genes / Proteins: 2,398
Interactions / Reactions: 3,529
Pathways: 13
Last Content Update: January 1st, 2012
Major Organisms
Relative Popularity9
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"Pathguide: the pathway resource list" is maintained by Gary Bader1.
The website was originally created by Michael Cary 2 and was significantly updated and redesigned by Vuk Pavlovic1.
Thanks to Emek Demir for the Pathguide name.

1. Bader Lab
2. Sander Group

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