Pathguide: the pathway resource list
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Full Record: PANTHER  
Full NameProtein ANalysis THrough Evolutionary Relationships
Last ObservedMarch 2nd, 2017
DescriptionMainly a database of protein families, PANTHER also contains a number of signaling pathways associated with proteins in the database. It is focused on higher eukaryotes.
Sample Data URL 
Data SourcePrimary
AvailabilityFree to all users
PubMed ArticlesThe PANTHER database of protein families, subfamilies, functions and pathways.
Mi H, Lazareva-Ulitsky B, Loo R, Kejariwal A, Vandergriff J, Rabkin S, Guo N, Muruganujan A, Doremieux O, Campbell MJ, Kitano H, Thomas PD.
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D284-8.

Applications for protein sequence-function evolution data: mRNA/protein expression analysis and coding SNP scoring tools.
Thomas PD, Kejariwal A, Guo N, Mi H, Campbell MJ, Muruganujan A, Lazareva-Ulitsky B.
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W645-50.

PANTHER version 6: protein sequence and function evolution data with expanded representation of biological pathways.
Mi H, Guo N, Kejariwal A, Thomas PD.
Nucleic Acids Res. 2007 Jan;35(Database issue):D247-52. Epub 2006 Nov 27.

PANTHER pathway: an ontology-based pathway database coupled with data analysis tools.
Mi H, Thomas P
Methods Mol Biol. 2009;563:123-40.

PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology Consortium.
Mi H, Dong Q, Muruganujan A, Gaudet P, Lewis S, Thomas PD.
Nucleic Acids Res. 2010;38 (Database issue):D204-D210

GIGA: a simple, efficient algorithm for gene tree inference in the genomic age.
Thomas PD.
BMC Bioinformatics. 2010 Jun 9;11:312.

PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees.
Mi H, Muruganujan A, Thomas PD
Nucleic Acids Res. 2013 Jan;41(Database issue):D377-86.

Large-scale gene function analysis with the PANTHER classification system.
Mi H, Muruganujan A, Casagrande JT, Thomas PD.
Nat Protoc. 2013 Aug;8(8):1551-66.

PANTHER version 10: expanded protein families and functions, and analysis tools.
Mi H, Poudel S, Muruganujan A, Casagrande JT, Thomas PD.
Nucleic Acids Res. 2016 Jan 4;44(D1):D336-42.

PANTHER-PSEP: predicting disease-causing genetic variants using position-specific evolutionary preservation.
Tang H, Thomas PD.
Bioinformatics. 2016 Jul 15;32(14):2230-2.

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements.
Mi H, Huang X, Muruganujan A, Tang H, Mills C, Kang D, Thomas PD.
Nucleic Acids Res. 2017 Jan 4;45(D1):D183-D189.

Types of DataSignaling Pathways, Pathway Diagrams, Protein Sequence Focused
Types of ToolsExpression analysis, Pathway diagram tools
Genes / Proteins: 1,378,820
Pathways: 177
Last Content Update: July 10th, 2017
Major OrganismsRattus norvegicus, Caenorhabditis elegans, Homo sapiens, Saccharomyces cerevisiae, Mus musculus, Schizosaccharomyces pombe, Danio rerio, Dictyostelium discoideum, Drosophila melanogaster
Relative Popularity1640
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"Pathguide: the pathway resource list" is maintained by Gary Bader1.
The website was originally created by Michael Cary 2 and was significantly updated and redesigned by Vuk Pavlovic1.
Thanks to Emek Demir for the Pathguide name.

1. Bader Lab
2. Sander Group

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